258386

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 40737..41284 Replicon plasmid p1
Accession NZ_CP104540
Organism Escherichia coli strain E6

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag N5O76_RS23825 Protein ID WP_097309154.1
Coordinates 40737..41015 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag N5O76_RS23830 Protein ID WP_000079941.1
Coordinates 41015..41284 (-) Length 90 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O76_RS23795 (37001) 37001..37135 - 135 WP_249531455.1 hypothetical protein -
N5O76_RS23800 (37095) 37095..38036 - 942 WP_001312841.1 3-deoxy-7-phosphoheptulonate synthase -
N5O76_RS23805 (38217) 38217..38517 + 301 Protein_29 hypothetical protein -
N5O76_RS23810 (38595) 38595..38942 - 348 WP_000142437.1 DUF6404 family protein -
N5O76_RS23815 (39244) 39244..39726 - 483 WP_001311056.1 hypothetical protein -
N5O76_RS23820 (39843) 39843..40691 - 849 WP_001058005.1 3'-5' exonuclease -
N5O76_RS23825 (40737) 40737..41015 - 279 WP_097309154.1 type II toxin-antitoxin system toxin YacB Toxin
N5O76_RS23830 (41015) 41015..41284 - 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
N5O76_RS23835 (41806) 41806..43034 + 1229 WP_112030635.1 IS3-like element IS2 family transposase -
N5O76_RS23840 (43264) 43264..44504 + 1241 Protein_36 HlyD family secretion protein -
N5O76_RS23845 (44611) 44611..44883 + 273 Protein_37 cysteine peptidase family C39 domain-containing protein -
N5O76_RS23850 (45064) 45064..46050 + 987 Protein_38 IS4-like element IS421 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iroB / iroC / iroD / iroE / iroN / vat / iutA / iucD / iucC / iucB / iucA 1..182456 182456


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10799.42 Da        Isoelectric Point: 8.4615

>T258386 WP_097309154.1 NZ_CP104540:c41015-40737 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYSASNLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTVQKWP

Download         Length: 279 bp


Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT258386 WP_000079941.1 NZ_CP104540:c41284-41015 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References