258385

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4391683..4392180 Replicon chromosome
Accession NZ_CP104539
Organism Escherichia coli strain E6

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag N5O76_RS21435 Protein ID WP_001173343.1
Coordinates 4391683..4391856 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag N5O76_RS21440 Protein ID WP_000398619.1
Coordinates 4391884..4392180 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O76_RS21425 (4388353) 4388353..4389810 + 1458 WP_000856834.1 dipeptide/tripeptide permease DtpC -
N5O76_RS21430 (4390047) 4390047..4391564 + 1518 WP_001295074.1 lysine--tRNA ligase -
N5O76_RS21435 (4391683) 4391683..4391856 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
N5O76_RS21440 (4391884) 4391884..4392180 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
N5O76_RS21445 (4392407) 4392407..4392679 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
N5O76_RS21450 (4392691) 4392691..4392921 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
N5O76_RS21455 (4393102) 4393102..4394733 + 1632 WP_001216461.1 sensor histidine kinase -
N5O76_RS21460 (4394730) 4394730..4395449 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T258385 WP_001173343.1 NZ_CP104539:c4391856-4391683 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT258385 WP_000398619.1 NZ_CP104539:c4392180-4391884 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References