258382

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 4228526..4229861 Replicon chromosome
Accession NZ_CP104539
Organism Escherichia coli strain E6

Toxin (Protein)


Gene name sanaT Uniprot ID F4VMR9
Locus tag N5O76_RS20625 Protein ID WP_000342497.1
Coordinates 4228526..4229473 (-) Length 316 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID E0J2C6
Locus tag N5O76_RS20630 Protein ID WP_000152741.1
Coordinates 4229466..4229861 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O76_RS20595 (4224379) 4224379..4225095 + 717 WP_021534608.1 N-acetylneuraminic acid outer membrane channel NanC -
N5O76_RS20600 (4225115) 4225115..4226221 + 1107 WP_032217392.1 N-acetylneuraminate epimerase -
N5O76_RS20605 (4226286) 4226286..4227266 + 981 WP_053264536.1 sialate O-acetylesterase -
N5O76_RS20610 (4227274) 4227274..4227924 - 651 WP_001037963.1 HNH endonuclease -
N5O76_RS20615 (4228061) 4228061..4228204 + 144 Protein_4035 HNH endonuclease -
N5O76_RS20620 (4228303) 4228303..4228488 + 186 WP_000066585.1 hypothetical protein -
N5O76_RS20625 (4228526) 4228526..4229473 - 948 WP_000342497.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
N5O76_RS20630 (4229466) 4229466..4229861 - 396 WP_000152741.1 DUF6088 family protein Antitoxin
N5O76_RS20635 (4229931) 4229931..4230764 - 834 WP_053264535.1 DUF4942 domain-containing protein -
N5O76_RS20640 (4230879) 4230879..4231220 - 342 WP_089586169.1 TA system toxin CbtA family protein -
N5O76_RS20645 (4231251) 4231251..4231586 - 336 WP_053264533.1 type IV toxin-antitoxin system YeeU family antitoxin -
N5O76_RS20650 (4231586) 4231586..4232059 - 474 WP_001296921.1 DNA repair protein RadC -
N5O76_RS20655 (4232089) 4232089..4232907 - 819 WP_160347992.1 DUF932 domain-containing protein -
N5O76_RS20660 (4233143) 4233143..4234096 - 954 WP_053264531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimC / fimI / fimA / fimE / fimB 4218853..4249815 30962


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-303)

Antitoxin

Protein of unknown function DUF6088

(7-108)


Sequences

Toxin        


Download         Length: 316 a.a.        Molecular weight: 35588.79 Da        Isoelectric Point: 4.9737

>T258382 WP_000342497.1 NZ_CP104539:c4229473-4228526 [Escherichia coli]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGITGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSLLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYQMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA

Download         Length: 948 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14619.93 Da        Isoelectric Point: 11.6915

>AT258382 WP_000152741.1 NZ_CP104539:c4229861-4229466 [Escherichia coli]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRELVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVRYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L5BAQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A1L4ZXD4

References