Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3587462..3588080 Replicon chromosome
Accession NZ_CP104539
Organism Escherichia coli strain E6

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N5O76_RS17560 Protein ID WP_001291435.1
Coordinates 3587862..3588080 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N5O76_RS17555 Protein ID WP_000344800.1
Coordinates 3587462..3587836 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O76_RS17545 (3582551) 3582551..3583744 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N5O76_RS17550 (3583767) 3583767..3586916 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N5O76_RS17555 (3587462) 3587462..3587836 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N5O76_RS17560 (3587862) 3587862..3588080 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N5O76_RS17565 (3588252) 3588252..3588803 + 552 WP_000102564.1 maltose O-acetyltransferase -
N5O76_RS17570 (3588919) 3588919..3589389 + 471 WP_000136192.1 YlaC family protein -
N5O76_RS17575 (3589553) 3589553..3591103 + 1551 WP_001446396.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N5O76_RS17580 (3591145) 3591145..3591498 - 354 WP_000878140.1 DUF1428 domain-containing protein -
N5O76_RS17590 (3591877) 3591877..3592188 + 312 WP_000409911.1 MGMT family protein -
N5O76_RS17595 (3592219) 3592219..3592791 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258379 WP_001291435.1 NZ_CP104539:3587862-3588080 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT258379 WP_000344800.1 NZ_CP104539:3587462-3587836 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References