258378

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2433078..2434666 Replicon chromosome
Accession NZ_CP104539
Organism Escherichia coli strain E6

Toxin (Protein)


Gene name hipA Uniprot ID A0A8S7XCC6
Locus tag N5O76_RS11900 Protein ID WP_053264575.1
Coordinates 2433344..2434666 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N5O76_RS11895 Protein ID WP_001296726.1
Coordinates 2433078..2433344 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O76_RS11895 (2433078) 2433078..2433344 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N5O76_RS11900 (2433344) 2433344..2434666 + 1323 WP_053264575.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
N5O76_RS11905 (2434978) 2434978..2435186 + 209 Protein_2328 AraC family transcriptional regulator -
N5O76_RS11910 (2435618) 2435618..2436181 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
N5O76_RS11915 (2436542) 2436542..2437252 + 711 WP_053264576.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA 2433078..2449166 16088


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49349.94 Da        Isoelectric Point: 8.8783

>T258378 WP_053264575.1 NZ_CP104539:2433344-2434666 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT258378 WP_001296726.1 NZ_CP104539:2433078-2433344 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References