258372

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1414566..1415191 Replicon chromosome
Accession NZ_CP104539
Organism Escherichia coli strain E6

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag N5O76_RS06965 Protein ID WP_000911329.1
Coordinates 1414793..1415191 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag N5O76_RS06960 Protein ID WP_000450524.1
Coordinates 1414566..1414793 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O76_RS06935 (1410368) 1410368..1410838 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
N5O76_RS06940 (1410838) 1410838..1411410 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
N5O76_RS06945 (1411556) 1411556..1412434 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
N5O76_RS06950 (1412451) 1412451..1413485 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
N5O76_RS06955 (1413698) 1413698..1414411 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
N5O76_RS06960 (1414566) 1414566..1414793 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
N5O76_RS06965 (1414793) 1414793..1415191 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
N5O76_RS06970 (1415338) 1415338..1416201 + 864 WP_001267498.1 neutral zinc metallopeptidase -
N5O76_RS06975 (1416216) 1416216..1418231 + 2016 WP_053264617.1 tRNA cytosine(34) acetyltransferase TmcA -
N5O76_RS06980 (1418305) 1418305..1419003 + 699 WP_000679812.1 esterase -
N5O76_RS06985 (1419084) 1419084..1419284 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T258372 WP_000911329.1 NZ_CP104539:1414793-1415191 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT258372 WP_000450524.1 NZ_CP104539:1414566-1414793 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References