258370

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 911747..912401 Replicon chromosome
Accession NZ_CP104539
Organism Escherichia coli strain E6

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag N5O76_RS04530 Protein ID WP_000244781.1
Coordinates 911994..912401 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N5O76_RS04525 Protein ID WP_000354046.1
Coordinates 911747..912013 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O76_RS04500 (906916) 906916..907659 + 744 WP_000951951.1 SDR family oxidoreductase -
N5O76_RS04505 (907716) 907716..909149 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
N5O76_RS04510 (909194) 909194..909505 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
N5O76_RS04515 (909669) 909669..910328 + 660 WP_000250274.1 hemolysin III family protein -
N5O76_RS04520 (910524) 910524..911504 - 981 WP_000886095.1 tRNA-modifying protein YgfZ -
N5O76_RS04525 (911747) 911747..912013 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N5O76_RS04530 (911994) 911994..912401 + 408 WP_000244781.1 protein YgfX Toxin
N5O76_RS04535 (912441) 912441..912962 - 522 WP_001055874.1 flavodoxin FldB -
N5O76_RS04540 (913074) 913074..913970 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N5O76_RS04545 (913995) 913995..914705 + 711 WP_000715208.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5O76_RS04550 (914711) 914711..916444 + 1734 WP_000813218.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T258370 WP_000244781.1 NZ_CP104539:911994-912401 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT258370 WP_000354046.1 NZ_CP104539:911747-912013 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References