25837

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2471790..2472403 Replicon chromosome
Accession NC_016768
Organism Mycobacterium tuberculosis KZN 4207

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag TBSG_RS11825 Protein ID WP_003408465.1
Coordinates 2472014..2472403 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag TBSG_RS11820 Protein ID WP_003408469.1
Coordinates 2471790..2472017 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBSG_RS11800 2467682..2468392 + 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -
TBSG_RS11805 2468382..2468801 + 420 WP_003408483.1 hypothetical protein -
TBSG_RS11810 2468844..2470091 - 1248 WP_003408476.1 serine hydrolase -
TBSG_RS11815 2470088..2471572 - 1485 WP_009937637.1 biotin carboxylase -
TBSG_RS11820 2471790..2472017 + 228 WP_003408469.1 antitoxin Antitoxin
TBSG_RS11825 2472014..2472403 + 390 WP_003408465.1 PIN domain-containing protein Toxin
TBSG_RS11840 2473013..2473792 - 780 WP_003408460.1 IclR family transcriptional regulator -
TBSG_RS11845 2473806..2474624 - 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
TBSG_RS11850 2474677..2475026 - 350 Protein_2317 cupin domain-containing protein -
TBSG_RS11855 2475026..2475856 - 831 WP_003906661.1 cyclase family protein -
TBSG_RS11860 2475859..2476773 - 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T25837 WP_003408465.1 NC_016768:2472014-2472403 [Mycobacterium tuberculosis KZN 4207]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T25837 NC_016768:2472014-2472403 [Mycobacterium tuberculosis KZN 4207]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT25837 WP_003408469.1 NC_016768:2471790-2472017 [Mycobacterium tuberculosis KZN 4207]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT25837 NC_016768:2471790-2472017 [Mycobacterium tuberculosis KZN 4207]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References