Detailed information of TA system TA025836

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2451211..2451671
• Replicon: chromosome
• Accession: NC_016768
• Organism: Mycobacterium tuberculosis KZN 4207

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TKL9
• Locus tag: TBSG_RS11715
• Protein ID: WP_003898996.1
• Coordinates: 2451211..2451459 (-)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: TBSG_RS11720
• Protein ID: WP_009938412.1
• Coordinates: 2451459..2451671 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TBSG_RS11695	2447385..2447996	+	612	WP_003898999.1	isopentenyl-diphosphate Delta-isomerase	-
TBSG_RS11700	2447986..2448387	+	402	WP_003408538.1	hypothetical protein	-
TBSG_RS11705	2448672..2450372	-	1701	WP_003898998.1	serine/threonine protein kinase PknE	-
TBSG_RS11710	2450466..2451203	-	738	WP_003898997.1	hypothetical protein	-
TBSG_RS11715	2451211..2451459	-	249	WP_003898996.1	type II toxin-antitoxin system VapC family toxin	Toxin
TBSG_RS11720	2451459..2451671	-	213	WP_009938412.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
TBSG_RS11725	2451739..2453421	+	1683	WP_003898994.1	SulP family inorganic anion transporter	-
TBSG_RS11730	2453435..2453719	-	285	WP_003408522.1	DUF1876 domain-containing protein	-
TBSG_RS11735	2454006..2455193	+	1188	WP_003898992.1	nitrate transporter NarK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin VapB-like (2-69)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 8884.14 Da
• Isoelectric Point: 4.1074

>T25836 WP_003898996.1 NC_016768:c2451459-2451211 [Mycobacterium tuberculosis KZN 4207]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Nucleotide

• Length: 249 bp

>T25836 NC_016768:c2451459-2451211 [Mycobacterium tuberculosis KZN 4207]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7665.84 Da
• Isoelectric Point: 7.9917

>AT25836 WP_009938412.1 NC_016768:c2451671-2451459 [Mycobacterium tuberculosis KZN 4207]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCEALPVLDTRAADTILGYDERGLPA

Nucleotide

• Length: 213 bp

>AT25836 NC_016768:c2451671-2451459 [Mycobacterium tuberculosis KZN 4207]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGAGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Structures

Toxin

• AlphaFold DB: G0TKL9