Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870744..871398 Replicon chromosome
Accession NZ_CP104536
Organism Escherichia coli strain E3

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag N5O72_RS04320 Protein ID WP_000244777.1
Coordinates 870991..871398 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N5O72_RS04315 Protein ID WP_000354046.1
Coordinates 870744..871010 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O72_RS04290 (866032) 866032..866775 + 744 WP_000951948.1 SDR family oxidoreductase -
N5O72_RS04295 (866832) 866832..868265 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
N5O72_RS04300 (868310) 868310..868621 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
N5O72_RS04305 (868785) 868785..869444 + 660 WP_000250274.1 hemolysin III family protein -
N5O72_RS04310 (869521) 869521..870501 - 981 WP_000886061.1 tRNA-modifying protein YgfZ -
N5O72_RS04315 (870744) 870744..871010 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N5O72_RS04320 (870991) 870991..871398 + 408 WP_000244777.1 protein YgfX Toxin
N5O72_RS04325 (871438) 871438..871959 - 522 WP_001055874.1 flavodoxin FldB -
N5O72_RS04330 (872071) 872071..872967 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N5O72_RS04335 (872992) 872992..873702 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5O72_RS04340 (873708) 873708..875441 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T258351 WP_000244777.1 NZ_CP104536:870991-871398 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT258351 WP_000354046.1 NZ_CP104536:870744-871010 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References