Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 262889..263475 Replicon chromosome
Accession NZ_CP104536
Organism Escherichia coli strain E3

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag N5O72_RS01195 Protein ID WP_042014162.1
Coordinates 262889..263119 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag N5O72_RS01200 Protein ID WP_000593555.1
Coordinates 263116..263475 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O72_RS01185 (258926) 258926..261661 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
N5O72_RS01190 (261661) 261661..262785 + 1125 WP_001314210.1 ABC transporter permease -
N5O72_RS01195 (262889) 262889..263119 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
N5O72_RS01200 (263116) 263116..263475 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N5O72_RS01205 (263595) 263595..263996 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
N5O72_RS01210 (264002) 264002..264808 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
N5O72_RS01215 (264805) 264805..265569 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
N5O72_RS01220 (265569) 265569..266402 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
N5O72_RS01225 (266399) 266399..267343 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T258347 WP_042014162.1 NZ_CP104536:262889-263119 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT258347 WP_000593555.1 NZ_CP104536:263116-263475 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References