Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 4287082..4287896 Replicon chromosome
Accession NZ_CP104533
Organism Escherichia coli strain E10

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag N5O77_RS21310 Protein ID WP_001054376.1
Coordinates 4287082..4287339 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A8E0IVE5
Locus tag N5O77_RS21315 Protein ID WP_001350781.1
Coordinates 4287351..4287896 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O77_RS21285 (4282370) 4282370..4283476 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
N5O77_RS21290 (4283541) 4283541..4284521 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
N5O77_RS21295 (4284631) 4284631..4284836 + 206 Protein_4171 HNH endonuclease -
N5O77_RS21300 (4285104) 4285104..4286344 - 1241 Protein_4172 helicase YjhR -
N5O77_RS21305 (4286460) 4286460..4286591 + 132 WP_001309182.1 hypothetical protein -
N5O77_RS21310 (4287082) 4287082..4287339 + 258 WP_001054376.1 YjhX family toxin Toxin
N5O77_RS21315 (4287351) 4287351..4287896 + 546 WP_001350781.1 N-acetyltransferase Antitoxin
N5O77_RS21320 (4287952) 4287952..4288698 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
N5O77_RS21325 (4288867) 4288867..4289085 + 219 Protein_4177 hypothetical protein -
N5O77_RS21330 (4289123) 4289123..4289239 + 117 Protein_4178 VOC family protein -
N5O77_RS21335 (4289484) 4289484..4290605 + 1122 WP_000010829.1 M42 family metallopeptidase -
N5O77_RS21340 (4290602) 4290602..4290880 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
N5O77_RS21345 (4290892) 4290892..4292205 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4276868..4296120 19252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T258337 WP_001054376.1 NZ_CP104533:4287082-4287339 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19974.91 Da        Isoelectric Point: 6.3277

>AT258337 WP_001350781.1 NZ_CP104533:4287351-4287896 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAFIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure

References