Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3657372..3657990 Replicon chromosome
Accession NZ_CP104533
Organism Escherichia coli strain E10

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N5O77_RS18290 Protein ID WP_001291435.1
Coordinates 3657772..3657990 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N5O77_RS18285 Protein ID WP_000344800.1
Coordinates 3657372..3657746 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O77_RS18275 (3652462) 3652462..3653655 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N5O77_RS18280 (3653678) 3653678..3656827 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N5O77_RS18285 (3657372) 3657372..3657746 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N5O77_RS18290 (3657772) 3657772..3657990 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N5O77_RS18295 (3658164) 3658164..3658715 + 552 WP_000102543.1 maltose O-acetyltransferase -
N5O77_RS18300 (3658831) 3658831..3659301 + 471 WP_000136192.1 YlaC family protein -
N5O77_RS18305 (3659465) 3659465..3661015 + 1551 WP_001350616.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N5O77_RS18310 (3661057) 3661057..3661410 - 354 WP_000878140.1 DUF1428 domain-containing protein -
N5O77_RS18320 (3661789) 3661789..3662100 + 312 WP_000409908.1 MGMT family protein -
N5O77_RS18325 (3662131) 3662131..3662703 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258330 WP_001291435.1 NZ_CP104533:3657772-3657990 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT258330 WP_000344800.1 NZ_CP104533:3657372-3657746 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References