Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2215579..2216123 | Replicon | chromosome |
| Accession | NC_016768 | ||
| Organism | Mycobacterium tuberculosis KZN 4207 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | TBSG_RS10620 | Protein ID | WP_003409896.1 |
| Coordinates | 2215827..2216123 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | TBSG_RS10615 | Protein ID | WP_003409899.1 |
| Coordinates | 2215579..2215830 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TBSG_RS10585 | 2211306..2212103 | - | 798 | WP_003899101.1 | ABC transporter permease | - |
| TBSG_RS10595 | 2213002..2214222 | + | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| TBSG_RS10600 | 2214255..2214527 | + | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TBSG_RS10605 | 2214531..2214938 | + | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| TBSG_RS10610 | 2215098..2215592 | - | 495 | WP_003899099.1 | hypothetical protein | - |
| TBSG_RS10615 | 2215579..2215830 | + | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| TBSG_RS10620 | 2215827..2216123 | + | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| TBSG_RS10625 | 2216172..2216786 | + | 615 | WP_003901296.1 | hypothetical protein | - |
| TBSG_RS10630 | 2216675..2217220 | - | 546 | WP_003409891.1 | SecB-like chaperone | - |
| TBSG_RS10635 | 2217217..2217666 | - | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| TBSG_RS10640 | 2217708..2218085 | - | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| TBSG_RS22330 | 2218060..2218581 | + | 522 | WP_003904745.1 | hypothetical protein | - |
| TBSG_RS10650 | 2218555..2218866 | - | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| TBSG_RS10655 | 2218863..2219078 | - | 216 | WP_003409878.1 | antitoxin | - |
| TBSG_RS10660 | 2219318..2219614 | + | 297 | WP_003409877.1 | hypothetical protein | - |
| TBSG_RS10665 | 2219615..2219806 | + | 192 | WP_003409876.1 | hypothetical protein | - |
| TBSG_RS10670 | 2219827..2220729 | + | 903 | WP_003899097.1 | hypothetical protein | - |
| TBSG_RS10675 | 2220740..2221090 | + | 351 | WP_003899096.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T25833 WP_003409896.1 NC_016768:2215827-2216123 [Mycobacterium tuberculosis KZN 4207]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T25833 NC_016768:2215827-2216123 [Mycobacterium tuberculosis KZN 4207]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT25833 WP_003409899.1 NC_016768:2215579-2215830 [Mycobacterium tuberculosis KZN 4207]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT25833 NC_016768:2215579-2215830 [Mycobacterium tuberculosis KZN 4207]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |