Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2505652..2507240 Replicon chromosome
Accession NZ_CP104533
Organism Escherichia coli strain E10

Toxin (Protein)


Gene name hipA Uniprot ID B7MMY1
Locus tag N5O77_RS12365 Protein ID WP_001125475.1
Coordinates 2505918..2507240 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N5O77_RS12360 Protein ID WP_001332145.1
Coordinates 2505652..2505918 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O77_RS12345 (2502020) 2502020..2503471 + 1452 WP_001513806.1 tagaturonate reductase -
N5O77_RS12350 (2503668) 2503668..2504582 + 915 WP_001306069.1 bestrophin family protein -
N5O77_RS12355 (2504586) 2504586..2505344 - 759 WP_001286588.1 trans-aconitate 2-methyltransferase -
N5O77_RS12360 (2505652) 2505652..2505918 + 267 WP_001332145.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N5O77_RS12365 (2505918) 2505918..2507240 + 1323 WP_001125475.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
N5O77_RS12370 (2507550) 2507550..2507732 - 183 Protein_2421 hypothetical protein -
N5O77_RS12375 (2507866) 2507866..2508648 + 783 WP_001221834.1 SDR family oxidoreductase -
N5O77_RS12380 (2508892) 2508892..2508999 - 108 Protein_2423 hypothetical protein -
N5O77_RS12385 (2509424) 2509424..2509603 + 180 Protein_2424 fimbrial protein -
N5O77_RS12390 (2509602) 2509602..2510348 + 747 Protein_2425 fimbria/pilus outer membrane usher protein -
N5O77_RS12395 (2510362) 2510362..2510892 + 531 WP_000876778.1 fimbrial protein -
N5O77_RS12400 (2510905) 2510905..2511408 + 504 WP_000825468.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49426.24 Da        Isoelectric Point: 8.9380

>T258327 WP_001125475.1 NZ_CP104533:2505918-2507240 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.44 Da        Isoelectric Point: 6.2267

>AT258327 WP_001332145.1 NZ_CP104533:2505652-2505918 [Escherichia coli]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L5M8

Antitoxin

Source ID Structure

References