Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 25251..25798 Replicon plasmid p2
Accession NZ_CP104528
Organism Escherichia coli strain E8

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag N5O73_RS24155 Protein ID WP_001384452.1
Coordinates 25520..25798 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1M1SX19
Locus tag N5O73_RS24150 Protein ID WP_021546940.1
Coordinates 25251..25520 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O73_RS24130 (N5O73_24135) 22338..22535 + 198 WP_240100958.1 DUF2933 domain-containing protein -
N5O73_RS24135 (N5O73_24140) 22569..22994 - 426 Protein_22 peptidoglycan DD-metalloendopeptidase family protein -
N5O73_RS24140 (N5O73_24145) 23049..23753 + 705 WP_261246574.1 IS6-like element IS26 family transposase -
N5O73_RS24145 (N5O73_24150) 23806..24564 - 759 Protein_24 IS3 family transposase -
N5O73_RS24150 (N5O73_24155) 25251..25520 + 270 WP_021546940.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
N5O73_RS24155 (N5O73_24160) 25520..25798 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
N5O73_RS24160 (N5O73_24165) 25844..26395 + 552 Protein_27 3'-5' exonuclease -
N5O73_RS24165 (N5O73_24170) 26564..26739 + 176 Protein_28 integrase core domain-containing protein -
N5O73_RS24170 (N5O73_24175) 26812..27498 + 687 WP_023281065.1 DNA-binding transcriptional regulator rspR -
N5O73_RS24175 (N5O73_24180) 27595..28026 + 432 Protein_30 transposase -
N5O73_RS24185 (N5O73_24190) 28772..29023 - 252 WP_023281067.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..60907 60907
- inside IScluster/Tn - - 23049..28738 5689


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T258314 WP_001384452.1 NZ_CP104528:25520-25798 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10321.69 Da        Isoelectric Point: 8.8725

>AT258314 WP_021546940.1 NZ_CP104528:25251-25520 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMRRKVADK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1SX19

References