Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 123831..124366 Replicon plasmid p1
Accession NZ_CP104527
Organism Escherichia coli strain E8

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag N5O73_RS23850 Protein ID WP_000222771.1
Coordinates 124079..124366 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag N5O73_RS23845 Protein ID WP_001139206.1
Coordinates 123831..124082 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O73_RS23840 (N5O73_23845) 119280..123248 - 3969 Protein_126 helicase-related protein -
N5O73_RS23845 (N5O73_23850) 123831..124082 + 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N5O73_RS23850 (N5O73_23855) 124079..124366 + 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5O73_RS23855 (N5O73_23860) 124734..124847 - 114 Protein_129 alkaline phosphatase -
N5O73_RS23860 (N5O73_23865) 124846..125051 + 206 Protein_130 hypothetical protein -
N5O73_RS23865 (N5O73_23870) 125226..128780 - 3555 WP_261246519.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..163762 163762


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T258313 WP_000222771.1 NZ_CP104527:124079-124366 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT258313 WP_001139206.1 NZ_CP104527:123831-124082 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References