Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 53378..53900 Replicon plasmid p1
Accession NZ_CP104527
Organism Escherichia coli strain E8

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag N5O73_RS23465 Protein ID WP_000220560.1
Coordinates 53378..53659 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag N5O73_RS23470 Protein ID WP_000121743.1
Coordinates 53649..53900 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O73_RS23455 (N5O73_23460) 50599..51987 - 1389 WP_065898688.1 nitrate/nitrite transporter NarU -
N5O73_RS23460 (N5O73_23465) 52250..53230 + 981 WP_000019445.1 IS5-like element ISKpn26 family transposase -
N5O73_RS23465 (N5O73_23470) 53378..53659 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5O73_RS23470 (N5O73_23475) 53649..53900 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
N5O73_RS23475 (N5O73_23480) 55049..56017 + 969 WP_152946993.1 IS5-like element IS903B family transposase -
N5O73_RS23480 (N5O73_23485) 56177..56320 + 144 WP_152930453.1 hypothetical protein -
N5O73_RS23485 (N5O73_23490) 56381..56626 + 246 Protein_55 transposase -
N5O73_RS23490 (N5O73_23495) 56694..57845 + 1152 WP_152931003.1 IS30-like element IS30 family transposase -
N5O73_RS23495 (N5O73_23500) 57853..58115 - 263 Protein_57 transposase -
N5O73_RS23500 (N5O73_23505) 58190..58501 + 312 Protein_58 VRR-NUC domain-containing protein -
N5O73_RS23505 (N5O73_23510) 58568..58723 + 156 WP_032236586.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..163762 163762
- inside IScluster/Tn - - 52250..59996 7746


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T258311 WP_000220560.1 NZ_CP104527:c53659-53378 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT258311 WP_000121743.1 NZ_CP104527:c53900-53649 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References