Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3534912..3535530 Replicon chromosome
Accession NZ_CP104526
Organism Escherichia coli strain E8

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N5O73_RS17160 Protein ID WP_001291435.1
Coordinates 3535312..3535530 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N5O73_RS17155 Protein ID WP_000344800.1
Coordinates 3534912..3535286 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O73_RS17145 (3530001) 3530001..3531194 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N5O73_RS17150 (3531217) 3531217..3534366 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N5O73_RS17155 (3534912) 3534912..3535286 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N5O73_RS17160 (3535312) 3535312..3535530 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N5O73_RS17165 (3535702) 3535702..3536253 + 552 WP_000102564.1 maltose O-acetyltransferase -
N5O73_RS17170 (3536369) 3536369..3536839 + 471 WP_000136192.1 YlaC family protein -
N5O73_RS17175 (3537003) 3537003..3538553 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N5O73_RS17180 (3538595) 3538595..3538948 - 354 WP_000878140.1 DUF1428 domain-containing protein -
N5O73_RS17190 (3539327) 3539327..3539638 + 312 WP_000409911.1 MGMT family protein -
N5O73_RS17195 (3539669) 3539669..3540241 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258308 WP_001291435.1 NZ_CP104526:3535312-3535530 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT258308 WP_000344800.1 NZ_CP104526:3534912-3535286 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References