Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2386736..2388324 Replicon chromosome
Accession NZ_CP104526
Organism Escherichia coli strain E8

Toxin (Protein)


Gene name hipA Uniprot ID A0A2X9LRN3
Locus tag N5O73_RS11690 Protein ID WP_021559062.1
Coordinates 2387002..2388324 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N5O73_RS11685 Protein ID WP_001301023.1
Coordinates 2386736..2387002 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O73_RS11685 (2386736) 2386736..2387002 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N5O73_RS11690 (2387002) 2387002..2388324 + 1323 WP_021559062.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
N5O73_RS11695 (2388612) 2388612..2389559 - 948 WP_261246453.1 hypothetical protein -
N5O73_RS11700 (2390370) 2390370..2390729 - 360 WP_063078926.1 hypothetical protein -
N5O73_RS11705 (2390747) 2390747..2391685 - 939 WP_261246454.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49318.83 Da        Isoelectric Point: 8.7817

>T258306 WP_021559062.1 NZ_CP104526:2387002-2388324 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSSIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWRIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT258306 WP_001301023.1 NZ_CP104526:2386736-2387002 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X9LRN3

Antitoxin

Source ID Structure

References