Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1986..2533 Replicon plasmid p2
Accession NZ_CP104525
Organism Escherichia coli strain E7

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag N5O80_RS25995 Protein ID WP_001384452.1
Coordinates 2255..2533 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag N5O80_RS25990 Protein ID WP_000079941.1
Coordinates 1986..2255 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O80_RS25980 (46) 46..1077 + 1032 WP_000907875.1 plasmid replication initiator RepA -
N5O80_RS25985 (1773) 1773..1931 + 159 WP_000841008.1 hypothetical protein -
N5O80_RS25990 (1986) 1986..2255 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
N5O80_RS25995 (2255) 2255..2533 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
N5O80_RS26000 (2573) 2573..3421 + 849 WP_021573937.1 3'-5' exonuclease -
N5O80_RS26005 (3658) 3658..3783 - 126 Protein_5 MerR family transcriptional regulator -
N5O80_RS26010 (3778) 3778..5388 + 1611 Protein_6 DDE-type integrase/transposase/recombinase -
N5O80_RS26015 (5391) 5391..6251 + 861 WP_000344784.1 TniB family NTP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / qacE / aac(3)-VIa / ant(3'')-Ia - 1..111369 111369


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T258292 WP_001384452.1 NZ_CP104525:2255-2533 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT258292 WP_000079941.1 NZ_CP104525:1986-2255 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References