25829

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2161132..2161758 Replicon chromosome
Accession NC_016768
Organism Mycobacterium tuberculosis KZN 4207

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag TBSG_RS10325 Protein ID WP_003410075.1
Coordinates 2161132..2161530 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag TBSG_RS10330 Protein ID WP_003911750.1
Coordinates 2161531..2161758 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBSG_RS10300 2156731..2157987 + 1257 WP_003410095.1 HNH endonuclease -
TBSG_RS10305 2158115..2158705 - 591 WP_003899131.1 IS110 family transposase -
TBSG_RS10310 2158659..2159306 - 648 WP_071854215.1 transposase -
TBSG_RS21245 2159367..2159546 + 180 Protein_2012 hypothetical protein -
TBSG_RS10315 2159983..2160417 - 435 WP_003914358.1 DUF1398 domain-containing protein -
TBSG_RS10320 2160518..2160949 + 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
TBSG_RS10325 2161132..2161530 - 399 WP_003410075.1 PIN domain nuclease Toxin
TBSG_RS10330 2161531..2161758 - 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TBSG_RS10335 2162017..2163186 + 1170 WP_003899126.1 ATP-binding protein -
TBSG_RS10340 2163375..2163719 + 345 WP_003410065.1 ferredoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T25829 WP_003410075.1 NC_016768:c2161530-2161132 [Mycobacterium tuberculosis KZN 4207]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T25829 NC_016768:c2161530-2161132 [Mycobacterium tuberculosis KZN 4207]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT25829 WP_003911750.1 NC_016768:c2161758-2161531 [Mycobacterium tuberculosis KZN 4207]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp

>AT25829 NC_016768:c2161758-2161531 [Mycobacterium tuberculosis KZN 4207]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References