Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3882961..3883615 Replicon chromosome
Accession NZ_CP104523
Organism Escherichia coli strain E7

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag N5O80_RS18910 Protein ID WP_000244781.1
Coordinates 3882961..3883368 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N5O80_RS18915 Protein ID WP_000354046.1
Coordinates 3883349..3883615 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O80_RS18890 (3878918) 3878918..3880651 - 1734 WP_000813191.1 single-stranded-DNA-specific exonuclease RecJ -
N5O80_RS18895 (3880657) 3880657..3881367 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5O80_RS18900 (3881392) 3881392..3882288 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N5O80_RS18905 (3882400) 3882400..3882921 + 522 WP_001055874.1 flavodoxin FldB -
N5O80_RS18910 (3882961) 3882961..3883368 - 408 WP_000244781.1 protein YgfX Toxin
N5O80_RS18915 (3883349) 3883349..3883615 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N5O80_RS18920 (3883868) 3883868..3884848 + 981 WP_000886050.1 tRNA-modifying protein YgfZ -
N5O80_RS18925 (3884925) 3884925..3885584 - 660 WP_000250269.1 hemolysin III family protein -
N5O80_RS18930 (3885748) 3885748..3886059 - 312 WP_261306703.1 N(4)-acetylcytidine aminohydrolase -
N5O80_RS18935 (3886104) 3886104..3887537 + 1434 WP_001389468.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T258281 WP_000244781.1 NZ_CP104523:c3883368-3882961 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT258281 WP_000354046.1 NZ_CP104523:c3883615-3883349 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References