Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2307011..2308593 Replicon chromosome
Accession NZ_CP104523
Organism Escherichia coli strain E7

Toxin (Protein)


Gene name hipA Uniprot ID A0A0J2BJD7
Locus tag N5O80_RS11230 Protein ID WP_001125469.1
Coordinates 2307011..2308327 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N5O80_RS11235 Protein ID WP_001296726.1
Coordinates 2308327..2308593 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O80_RS11215 (2304400) 2304400..2305110 - 711 WP_001195165.1 fimbria/pilus periplasmic chaperone -
N5O80_RS11220 (2305472) 2305472..2306035 - 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
N5O80_RS11225 (2306469) 2306469..2306735 - 267 Protein_2193 AraC family transcriptional regulator -
N5O80_RS11230 (2307011) 2307011..2308327 - 1317 WP_001125469.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
N5O80_RS11235 (2308327) 2308327..2308593 - 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N5O80_RS11240 (2308786) 2308786..2309523 - 738 Protein_2196 autotransporter outer membrane beta-barrel domain-containing protein -
N5O80_RS11245 (2309517) 2309517..2310083 - 567 Protein_2197 FGGY family carbohydrate kinase -
N5O80_RS11250 (2310162) 2310162..2311115 - 954 WP_000154356.1 transcriptional regulator LsrR -
N5O80_RS11255 (2311364) 2311364..2312899 + 1536 WP_001194895.1 autoinducer 2 ABC transporter ATP-binding protein LsrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49275.91 Da        Isoelectric Point: 8.8783

>T258274 WP_001125469.1 NZ_CP104523:c2308327-2307011 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPQVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHRRLSREWY

Download         Length: 1317 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT258274 WP_001296726.1 NZ_CP104523:c2308593-2308327 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2BJD7

Antitoxin

Source ID Structure

References