Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1861888..1862672 Replicon chromosome
Accession NZ_CP104523
Organism Escherichia coli strain E7

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag N5O80_RS09015 Protein ID WP_000613624.1
Coordinates 1861888..1862382 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B1LI61
Locus tag N5O80_RS09020 Protein ID WP_001110446.1
Coordinates 1862379..1862672 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O80_RS08995 (1857081) 1857081..1858178 + 1098 WP_000589326.1 flagellar basal body P-ring protein FlgI -
N5O80_RS09000 (1858178) 1858178..1859119 + 942 WP_001317765.1 flagellar assembly peptidoglycan hydrolase FlgJ -
N5O80_RS09005 (1859185) 1859185..1860828 + 1644 WP_000096482.1 flagellar hook-associated protein FlgK -
N5O80_RS09010 (1860840) 1860840..1861793 + 954 WP_001212762.1 flagellar hook-associated protein FlgL -
N5O80_RS09015 (1861888) 1861888..1862382 - 495 WP_000613624.1 GNAT family N-acetyltransferase Toxin
N5O80_RS09020 (1862379) 1862379..1862672 - 294 WP_001110446.1 DUF1778 domain-containing protein Antitoxin
N5O80_RS09025 (1862806) 1862806..1865991 - 3186 WP_000827395.1 ribonuclease E -
N5O80_RS09030 (1866564) 1866564..1867559 + 996 WP_261306745.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18142.04 Da        Isoelectric Point: 7.7444

>T258269 WP_000613624.1 NZ_CP104523:c1862382-1861888 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIDRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11079.67 Da        Isoelectric Point: 10.5423

>AT258269 WP_001110446.1 NZ_CP104523:c1862672-1862379 [Escherichia coli]
MPAANNIPARRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829G775

References