Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1205595..1206213 Replicon chromosome
Accession NZ_CP104523
Organism Escherichia coli strain E7

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N5O80_RS05715 Protein ID WP_001291435.1
Coordinates 1205595..1205813 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N5O80_RS05720 Protein ID WP_000344800.1
Coordinates 1205839..1206213 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O80_RS05680 (1200884) 1200884..1201456 + 573 WP_000779821.1 YbaY family lipoprotein -
N5O80_RS05685 (1201487) 1201487..1201798 - 312 WP_000409911.1 MGMT family protein -
N5O80_RS05695 (1202177) 1202177..1202530 + 354 WP_000878140.1 DUF1428 domain-containing protein -
N5O80_RS05700 (1202572) 1202572..1204122 - 1551 WP_001317659.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N5O80_RS05705 (1204286) 1204286..1204756 - 471 WP_000136192.1 YlaC family protein -
N5O80_RS05710 (1204872) 1204872..1205423 - 552 WP_000102564.1 maltose O-acetyltransferase -
N5O80_RS05715 (1205595) 1205595..1205813 - 219 WP_001291435.1 HHA domain-containing protein Toxin
N5O80_RS05720 (1205839) 1205839..1206213 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N5O80_RS05725 (1206759) 1206759..1209908 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N5O80_RS05730 (1209931) 1209931..1211124 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258266 WP_001291435.1 NZ_CP104523:c1205813-1205595 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT258266 WP_000344800.1 NZ_CP104523:c1206213-1205839 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References