Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 279033..279530 Replicon chromosome
Accession NZ_CP104523
Organism Escherichia coli strain E7

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag N5O80_RS01295 Protein ID WP_001173343.1
Coordinates 279357..279530 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A1V2FLJ5
Locus tag N5O80_RS01290 Protein ID WP_001317561.1
Coordinates 279033..279329 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O80_RS01270 (275765) 275765..276484 - 720 WP_000611288.1 two-component system response regulator DcuR -
N5O80_RS01275 (276481) 276481..278112 - 1632 WP_001216477.1 sensor histidine kinase -
N5O80_RS01280 (278292) 278292..278522 + 231 WP_000371717.1 4Fe-4S mono-cluster protein YjdI -
N5O80_RS01285 (278534) 278534..278806 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
N5O80_RS01290 (279033) 279033..279329 + 297 WP_001317561.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
N5O80_RS01295 (279357) 279357..279530 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
N5O80_RS01300 (279649) 279649..281166 - 1518 WP_000003805.1 lysine--tRNA ligase -
N5O80_RS01305 (281403) 281403..282860 - 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T258262 WP_001173343.1 NZ_CP104523:279357-279530 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT258262 WP_001317561.1 NZ_CP104523:279033-279329 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMSFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2FLJ5

References