Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4409782..4410413 Replicon chromosome
Accession NZ_CP104521
Organism Escherichia coli strain E5

Toxin (Protein)


Gene name hicA Uniprot ID L4J012
Locus tag N5O78_RS21465 Protein ID WP_001260301.1
Coordinates 4410138..4410413 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IZA1
Locus tag N5O78_RS21460 Protein ID WP_000593557.1
Coordinates 4409782..4410141 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O78_RS21435 (4405914) 4405914..4406858 + 945 WP_000947063.1 nickel ABC transporter permease subunit NikB -
N5O78_RS21440 (4406855) 4406855..4407688 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
N5O78_RS21445 (4407688) 4407688..4408452 + 765 WP_001136206.1 nickel import ATP-binding protein NikD -
N5O78_RS21450 (4408449) 4408449..4409255 + 807 WP_000173650.1 nickel import ATP-binding protein NikE -
N5O78_RS21455 (4409261) 4409261..4409662 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
N5O78_RS21460 (4409782) 4409782..4410141 - 360 WP_000593557.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N5O78_RS21465 (4410138) 4410138..4410413 - 276 WP_001260301.1 type II toxin-antitoxin system HicA family toxin Toxin
N5O78_RS21470 (4410486) 4410486..4411610 - 1125 WP_001318088.1 ABC transporter permease -
N5O78_RS21475 (4411610) 4411610..4414345 - 2736 WP_000149178.1 ribosome-associated ATPase/putative transporter RbbA -
N5O78_RS21480 (4414342) 4414342..4415409 - 1068 WP_000361470.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.87 Da        Isoelectric Point: 10.6128

>T258256 WP_001260301.1 NZ_CP104521:c4410413-4410138 [Escherichia coli]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13389.28 Da        Isoelectric Point: 5.1987

>AT258256 WP_000593557.1 NZ_CP104521:c4410141-4409782 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLTNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L4J012

Antitoxin

Source ID Structure
AlphaFold DB L4IZA1

References