Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3883725..3884557 Replicon chromosome
Accession NZ_CP104521
Organism Escherichia coli strain E5

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag N5O78_RS18805 Protein ID WP_000854753.1
Coordinates 3884183..3884557 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag N5O78_RS18800 Protein ID WP_001278232.1
Coordinates 3883725..3884093 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O78_RS18765 (3879568) 3879568..3880248 + 681 WP_001593697.1 WYL domain-containing protein -
N5O78_RS18770 (3880396) 3880396..3881073 + 678 WP_094122412.1 hypothetical protein -
N5O78_RS18775 (3881079) 3881079..3881312 + 234 WP_001278287.1 DUF905 family protein -
N5O78_RS18780 (3881411) 3881411..3882229 + 819 WP_094122413.1 DUF932 domain-containing protein -
N5O78_RS18785 (3882311) 3882311..3882790 + 480 WP_000860065.1 antirestriction protein -
N5O78_RS18790 (3882802) 3882802..3883278 + 477 WP_001186710.1 RadC family protein -
N5O78_RS18795 (3883341) 3883341..3883562 + 222 WP_000692303.1 DUF987 domain-containing protein -
N5O78_RS18800 (3883725) 3883725..3884093 + 369 WP_001278232.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
N5O78_RS18805 (3884183) 3884183..3884557 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
N5O78_RS18810 (3884554) 3884554..3885042 + 489 WP_000777541.1 DUF5983 family protein -
N5O78_RS18815 (3885054) 3885054..3885251 + 198 WP_000839281.1 DUF957 domain-containing protein -
N5O78_RS18820 (3885348) 3885348..3885917 + 570 WP_001290247.1 DUF4942 domain-containing protein -
N5O78_RS18825 (3886197) 3886197..3886733 - 537 WP_000942807.1 GspM family type II secretion system protein YghD -
N5O78_RS18830 (3886735) 3886735..3887912 - 1178 Protein_3678 type II secretion system protein GspL -
N5O78_RS18835 (3887909) 3887909..3888886 - 978 WP_000633196.1 type II secretion system minor pseudopilin GspK -
N5O78_RS18840 (3888883) 3888883..3889488 - 606 WP_001318033.1 type II secretion system minor pseudopilin GspJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T258253 WP_000854753.1 NZ_CP104521:3884183-3884557 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp


Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT258253 WP_001278232.1 NZ_CP104521:3883725-3884093 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0


Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References