Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3670308..3670962 Replicon chromosome
Accession NZ_CP104521
Organism Escherichia coli strain E5

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag N5O78_RS17740 Protein ID WP_000244781.1
Coordinates 3670308..3670715 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N5O78_RS17745 Protein ID WP_000354046.1
Coordinates 3670696..3670962 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O78_RS17720 (3666265) 3666265..3667998 - 1734 WP_000813191.1 single-stranded-DNA-specific exonuclease RecJ -
N5O78_RS17725 (3668004) 3668004..3668714 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5O78_RS17730 (3668739) 3668739..3669635 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N5O78_RS17735 (3669747) 3669747..3670268 + 522 WP_001055874.1 flavodoxin FldB -
N5O78_RS17740 (3670308) 3670308..3670715 - 408 WP_000244781.1 protein YgfX Toxin
N5O78_RS17745 (3670696) 3670696..3670962 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N5O78_RS17750 (3671215) 3671215..3672195 + 981 WP_000886050.1 tRNA-modifying protein YgfZ -
N5O78_RS17755 (3672272) 3672272..3672931 - 660 WP_000250269.1 hemolysin III family protein -
N5O78_RS17760 (3673095) 3673095..3673406 - 312 WP_001182953.1 N(4)-acetylcytidine aminohydrolase -
N5O78_RS17765 (3673451) 3673451..3674884 + 1434 WP_001389468.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T258252 WP_000244781.1 NZ_CP104521:c3670715-3670308 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT258252 WP_000354046.1 NZ_CP104521:c3670962-3670696 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References