Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3222906..3223531 Replicon chromosome
Accession NZ_CP104521
Organism Escherichia coli strain E5

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag N5O78_RS15710 Protein ID WP_000911329.1
Coordinates 3222906..3223304 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag N5O78_RS15715 Protein ID WP_000450524.1
Coordinates 3223304..3223531 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O78_RS15690 (3218813) 3218813..3219013 + 201 WP_000383836.1 YpfN family protein -
N5O78_RS15695 (3219094) 3219094..3219792 - 699 WP_000679819.1 esterase -
N5O78_RS15700 (3219866) 3219866..3221881 - 2016 WP_000829310.1 tRNA cytosine(34) acetyltransferase TmcA -
N5O78_RS15705 (3221896) 3221896..3222759 - 864 WP_001267498.1 neutral zinc metallopeptidase -
N5O78_RS15710 (3222906) 3222906..3223304 - 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
N5O78_RS15715 (3223304) 3223304..3223531 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
N5O78_RS15720 (3223688) 3223688..3224401 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
N5O78_RS15725 (3224614) 3224614..3225648 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
N5O78_RS15730 (3225665) 3225665..3226543 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
N5O78_RS15735 (3226689) 3226689..3227261 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
N5O78_RS15740 (3227261) 3227261..3227731 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T258251 WP_000911329.1 NZ_CP104521:c3223304-3222906 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT258251 WP_000450524.1 NZ_CP104521:c3223531-3223304 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References