Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2178757..2180339 Replicon chromosome
Accession NZ_CP104521
Organism Escherichia coli strain E5

Toxin (Protein)


Gene name hipA Uniprot ID A0A0J2BJD7
Locus tag N5O78_RS10480 Protein ID WP_001125469.1
Coordinates 2178757..2180073 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N5O78_RS10485 Protein ID WP_001296726.1
Coordinates 2180073..2180339 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O78_RS10465 (2176146) 2176146..2176856 - 711 WP_001195165.1 fimbria/pilus periplasmic chaperone -
N5O78_RS10470 (2177218) 2177218..2177781 - 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
N5O78_RS10475 (2178215) 2178215..2178481 - 267 Protein_2043 AraC family transcriptional regulator -
N5O78_RS10480 (2178757) 2178757..2180073 - 1317 WP_001125469.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
N5O78_RS10485 (2180073) 2180073..2180339 - 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N5O78_RS10490 (2180532) 2180532..2182421 - 1890 Protein_2046 autotransporter barrel domain-containing lipoprotein -
N5O78_RS10495 (2182571) 2182571..2184163 - 1593 WP_000113152.1 autoinducer-2 kinase -
N5O78_RS10500 (2184242) 2184242..2185195 - 954 WP_000154356.1 transcriptional regulator LsrR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49275.91 Da        Isoelectric Point: 8.8783

>T258245 WP_001125469.1 NZ_CP104521:c2180073-2178757 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPQVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHRRLSREWY

Download         Length: 1317 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT258245 WP_001296726.1 NZ_CP104521:c2180339-2180073 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2BJD7

Antitoxin

Source ID Structure

References