Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2091972..2092608 Replicon chromosome
Accession NZ_CP104521
Organism Escherichia coli strain E5

Toxin (Protein)


Gene name hicA Uniprot ID A0A5F1EUB3
Locus tag N5O78_RS10110 Protein ID WP_000813796.1
Coordinates 2091972..2092148 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N5O78_RS10115 Protein ID WP_076838470.1
Coordinates 2092192..2092608 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O78_RS10090 (2087594) 2087594..2088766 - 1173 WP_001236216.1 BenE family transporter YdcO -
N5O78_RS10095 (2088858) 2088858..2089394 + 537 WP_000429147.1 DNA-binding transcriptional regulator SutR -
N5O78_RS10100 (2089467) 2089467..2091428 + 1962 WP_001317809.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N5O78_RS10105 (2091520) 2091520..2091750 - 231 WP_000494243.1 YncJ family protein -
N5O78_RS10110 (2091972) 2091972..2092148 + 177 WP_000813796.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N5O78_RS10115 (2092192) 2092192..2092608 + 417 WP_076838470.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N5O78_RS10120 (2092687) 2092687..2094093 + 1407 WP_000760605.1 PLP-dependent aminotransferase family protein -
N5O78_RS10125 (2094338) 2094338..2095483 + 1146 WP_094122354.1 ABC transporter substrate-binding protein -
N5O78_RS10130 (2095501) 2095501..2096514 + 1014 WP_000220433.1 ABC transporter ATP-binding protein -
N5O78_RS10135 (2096515) 2096515..2097456 + 942 WP_001251307.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.78 Da        Isoelectric Point: 11.5666

>T258244 WP_000813796.1 NZ_CP104521:2091972-2092148 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLN

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15219.59 Da        Isoelectric Point: 4.5908

>AT258244 WP_076838470.1 NZ_CP104521:2092192-2092608 [Escherichia coli]
MRYPVTLTPAPEGGYVVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLTNNDHFIEVPLSIASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5F1EUB3

Antitoxin

Source ID Structure

References