Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1536802..1537507 Replicon chromosome
Accession NZ_CP104521
Organism Escherichia coli strain E5

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag N5O78_RS07365 Protein ID WP_000539521.1
Coordinates 1537121..1537507 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N5O78_RS07360 Protein ID WP_001280945.1
Coordinates 1536802..1537131 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O78_RS07345 (1531959) 1531959..1532870 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
N5O78_RS07350 (1533048) 1533048..1535396 + 2349 Protein_1425 EAL domain-containing protein -
N5O78_RS07355 (1535404) 1535404..1536732 + 1329 WP_096002626.1 GGDEF domain-containing protein -
N5O78_RS07360 (1536802) 1536802..1537131 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
N5O78_RS07365 (1537121) 1537121..1537507 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5O78_RS07370 (1537733) 1537733..1539058 - 1326 WP_000049378.1 30S ribosomal protein S12 methylthiotransferase RimO -
N5O78_RS07375 (1539271) 1539271..1539654 + 384 WP_000497137.1 biofilm formation regulator BssR -
N5O78_RS07380 (1539765) 1539765..1540880 + 1116 WP_000555041.1 aldose sugar dehydrogenase YliI -
N5O78_RS07385 (1540877) 1540877..1541503 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T258242 WP_000539521.1 NZ_CP104521:c1537507-1537121 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT258242 WP_001280945.1 NZ_CP104521:c1537131-1536802 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References