Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1145010..1145628 Replicon chromosome
Accession NZ_CP104521
Organism Escherichia coli strain E5

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N5O78_RS05415 Protein ID WP_001291435.1
Coordinates 1145010..1145228 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N5O78_RS05420 Protein ID WP_000344800.1
Coordinates 1145254..1145628 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O78_RS05380 (1140299) 1140299..1140871 + 573 WP_000779821.1 YbaY family lipoprotein -
N5O78_RS05385 (1140902) 1140902..1141213 - 312 WP_000409911.1 MGMT family protein -
N5O78_RS05395 (1141592) 1141592..1141945 + 354 WP_000878140.1 DUF1428 domain-containing protein -
N5O78_RS05400 (1141987) 1141987..1143537 - 1551 WP_001317659.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N5O78_RS05405 (1143701) 1143701..1144171 - 471 WP_000136192.1 YlaC family protein -
N5O78_RS05410 (1144287) 1144287..1144838 - 552 WP_000102564.1 maltose O-acetyltransferase -
N5O78_RS05415 (1145010) 1145010..1145228 - 219 WP_001291435.1 HHA domain-containing protein Toxin
N5O78_RS05420 (1145254) 1145254..1145628 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N5O78_RS05425 (1146174) 1146174..1149323 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N5O78_RS05430 (1149346) 1149346..1150539 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258240 WP_001291435.1 NZ_CP104521:c1145228-1145010 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT258240 WP_000344800.1 NZ_CP104521:c1145628-1145254 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References