Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1605023..1605675 Replicon chromosome
Accession NC_016768
Organism Mycobacterium tuberculosis KZN 4207

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag TBSG_RS07695 Protein ID WP_003412752.1
Coordinates 1605023..1605448 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag TBSG_RS07700 Protein ID WP_003412749.1
Coordinates 1605454..1605675 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBSG_RS07670 1600028..1600585 + 558 WP_003412768.1 MaoC family dehydratase -
TBSG_RS07675 1600582..1601403 + 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
TBSG_RS07680 1601662..1602765 + 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
TBSG_RS07685 1602776..1603822 + 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
TBSG_RS07690 1603819..1605000 + 1182 WP_003899351.1 2-oxo acid dehydrogenase subunit E2 -
TBSG_RS07695 1605023..1605448 - 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
TBSG_RS07700 1605454..1605675 - 222 WP_003412749.1 antitoxin Antitoxin
TBSG_RS07715 1607242..1607838 - 597 Protein_1511 hypothetical protein -
TBSG_RS07720 1607828..1608451 - 624 WP_003900858.1 TIGR00725 family protein -
TBSG_RS07725 1608587..1608793 + 207 WP_003899347.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1605930..1606814 884


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T25824 WP_003412752.1 NC_016768:c1605448-1605023 [Mycobacterium tuberculosis KZN 4207]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T25824 NC_016768:c1605448-1605023 [Mycobacterium tuberculosis KZN 4207]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCTAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT25824 WP_003412749.1 NC_016768:c1605675-1605454 [Mycobacterium tuberculosis KZN 4207]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT25824 NC_016768:c1605675-1605454 [Mycobacterium tuberculosis KZN 4207]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References