258230

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4128320..4128974 Replicon chromosome
Accession NZ_CP104516
Organism Escherichia coli strain E4

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag N5O79_RS20565 Protein ID WP_000244777.1
Coordinates 4128567..4128974 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N5O79_RS20560 Protein ID WP_000354046.1
Coordinates 4128320..4128586 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O79_RS20535 (4123489) 4123489..4124232 + 744 WP_000951964.1 SDR family oxidoreductase -
N5O79_RS20540 (4124289) 4124289..4125722 - 1434 WP_140441369.1 6-phospho-beta-glucosidase BglA -
N5O79_RS20545 (4125767) 4125767..4126078 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
N5O79_RS20550 (4126242) 4126242..4126901 + 660 WP_000250274.1 hemolysin III family protein -
N5O79_RS20555 (4127097) 4127097..4128077 - 981 WP_000886083.1 tRNA-modifying protein YgfZ -
N5O79_RS20560 (4128320) 4128320..4128586 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N5O79_RS20565 (4128567) 4128567..4128974 + 408 WP_000244777.1 protein YgfX Toxin
N5O79_RS20570 (4129014) 4129014..4129535 - 522 WP_001055874.1 flavodoxin FldB -
N5O79_RS20575 (4129647) 4129647..4130543 + 897 WP_000806628.1 site-specific tyrosine recombinase XerD -
N5O79_RS20580 (4130568) 4130568..4131278 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5O79_RS20585 (4131284) 4131284..4133017 + 1734 WP_000813201.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T258230 WP_000244777.1 NZ_CP104516:4128567-4128974 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT258230 WP_000354046.1 NZ_CP104516:4128320-4128586 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References