Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 2797618..2798543 | Replicon | chromosome |
| Accession | NZ_CP104516 | ||
| Organism | Escherichia coli strain E4 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | N5O79_RS14200 | Protein ID | WP_014640052.1 |
| Coordinates | 2797618..2798004 (-) | Length | 129 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | - |
| Locus tag | N5O79_RS14205 | Protein ID | WP_024174200.1 |
| Coordinates | 2798034..2798543 (-) | Length | 170 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N5O79_RS14165 (2793063) | 2793063..2793323 | - | 261 | WP_001191669.1 | helix-turn-helix transcriptional regulator | - |
| N5O79_RS14170 (2793421) | 2793421..2794113 | + | 693 | WP_001345148.1 | helix-turn-helix transcriptional regulator | - |
| N5O79_RS14175 (2794816) | 2794816..2795178 | + | 363 | WP_000135680.1 | protein YfdP | - |
| N5O79_RS14180 (2795244) | 2795244..2796068 | + | 825 | WP_000081311.1 | DUF2303 family protein | - |
| N5O79_RS14185 (2796257) | 2796257..2797039 | + | 783 | WP_047654657.1 | hypothetical protein | - |
| N5O79_RS14190 (2797076) | 2797076..2797357 | + | 282 | WP_001093916.1 | pyocin activator PrtN family protein | - |
| N5O79_RS14195 (2797405) | 2797405..2797578 | - | 174 | WP_000390072.1 | hypothetical protein | - |
| N5O79_RS14200 (2797618) | 2797618..2798004 | - | 387 | WP_014640052.1 | hypothetical protein | Toxin |
| N5O79_RS14205 (2798034) | 2798034..2798543 | - | 510 | WP_024174200.1 | Panacea domain-containing protein | Antitoxin |
| N5O79_RS14210 (2798860) | 2798860..2798964 | - | 105 | Protein_2791 | tRNA-dihydrouridine synthase | - |
| N5O79_RS14215 (2799327) | 2799327..2800348 | - | 1022 | Protein_2792 | DUF2713 domain-containing protein | - |
| N5O79_RS14220 (2800667) | 2800667..2801182 | + | 516 | WP_001295691.1 | zinc uptake transcriptional repressor Zur | - |
| N5O79_RS14225 (2801224) | 2801224..2801433 | - | 210 | WP_001030593.1 | CsbD family protein | - |
| N5O79_RS14230 (2801549) | 2801549..2802874 | - | 1326 | WP_001301116.1 | MATE family efflux transporter DinF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2756816..2803555 | 46739 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 129 a.a. Molecular weight: 14465.40 Da Isoelectric Point: 5.4833
>T258227 WP_014640052.1 NZ_CP104516:c2798004-2797618 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
Download Length: 387 bp
Antitoxin
Download Length: 170 a.a. Molecular weight: 19559.39 Da Isoelectric Point: 5.3338
>AT258227 WP_024174200.1 NZ_CP104516:c2798543-2798034 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS
Download Length: 510 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|