Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 2417320..2418134 Replicon chromosome
Accession NZ_CP104516
Organism Escherichia coli strain E4

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag N5O79_RS12250 Protein ID WP_001054376.1
Coordinates 2417320..2417577 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag N5O79_RS12255 Protein ID WP_001309181.1
Coordinates 2417589..2418134 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O79_RS12225 (2412608) 2412608..2413714 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
N5O79_RS12230 (2413779) 2413779..2414759 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
N5O79_RS12235 (2414869) 2414869..2415074 + 206 Protein_2401 HNH endonuclease -
N5O79_RS12240 (2415342) 2415342..2416582 - 1241 Protein_2402 helicase YjhR -
N5O79_RS12245 (2416698) 2416698..2416829 + 132 WP_261307154.1 GNAT family N-acetyltransferase -
N5O79_RS12250 (2417320) 2417320..2417577 + 258 WP_001054376.1 YjhX family toxin Toxin
N5O79_RS12255 (2417589) 2417589..2418134 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
N5O79_RS12260 (2418190) 2418190..2418936 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
N5O79_RS12265 (2419105) 2419105..2419323 + 219 Protein_2407 hypothetical protein -
N5O79_RS12270 (2419361) 2419361..2419477 + 117 Protein_2408 VOC family protein -
N5O79_RS12275 (2419722) 2419722..2420843 + 1122 WP_000010829.1 M42 family metallopeptidase -
N5O79_RS12280 (2420840) 2420840..2421118 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
N5O79_RS12285 (2421130) 2421130..2422443 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T258224 WP_001054376.1 NZ_CP104516:2417320-2417577 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT258224 WP_001309181.1 NZ_CP104516:2417589-2418134 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References