258219

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1745981..1746599 Replicon chromosome
Accession NZ_CP104516
Organism Escherichia coli strain E4

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N5O79_RS08985 Protein ID WP_001291435.1
Coordinates 1746381..1746599 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N5O79_RS08980 Protein ID WP_000344800.1
Coordinates 1745981..1746355 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O79_RS08970 (1741070) 1741070..1742263 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N5O79_RS08975 (1742286) 1742286..1745435 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N5O79_RS08980 (1745981) 1745981..1746355 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N5O79_RS08985 (1746381) 1746381..1746599 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N5O79_RS08990 (1746771) 1746771..1747322 + 552 WP_000102564.1 maltose O-acetyltransferase -
N5O79_RS08995 (1747438) 1747438..1747908 + 471 WP_000136192.1 YlaC family protein -
N5O79_RS09000 (1748072) 1748072..1749622 + 1551 WP_261307134.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N5O79_RS09005 (1749664) 1749664..1750017 - 354 WP_000878140.1 DUF1428 domain-containing protein -
N5O79_RS09015 (1750396) 1750396..1750707 + 312 WP_000409911.1 MGMT family protein -
N5O79_RS09020 (1750738) 1750738..1751310 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258219 WP_001291435.1 NZ_CP104516:1746381-1746599 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT258219 WP_000344800.1 NZ_CP104516:1745981-1746355 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References