258218

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 712612..713250 Replicon chromosome
Accession NZ_CP104516
Organism Escherichia coli strain E4

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N5O79_RS03755 Protein ID WP_000813794.1
Coordinates 713074..713250 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N5O79_RS03750 Protein ID WP_001270286.1
Coordinates 712612..713028 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O79_RS03730 (707764) 707764..708705 - 942 WP_001251313.1 ABC transporter permease -
N5O79_RS03735 (708706) 708706..709719 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
N5O79_RS03740 (709737) 709737..710882 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
N5O79_RS03745 (711127) 711127..712533 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
N5O79_RS03750 (712612) 712612..713028 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N5O79_RS03755 (713074) 713074..713250 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N5O79_RS03760 (713472) 713472..713702 + 231 WP_000494244.1 YncJ family protein -
N5O79_RS03765 (713794) 713794..715755 - 1962 WP_261307095.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N5O79_RS03770 (715828) 715828..716364 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
N5O79_RS03775 (716456) 716456..717631 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T258218 WP_000813794.1 NZ_CP104516:c713250-713074 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT258218 WP_001270286.1 NZ_CP104516:c713028-712612 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References