Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 27892..28439 Replicon plasmid p2
Accession NZ_CP104511
Organism Escherichia coli strain E2

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag N5O74_RS26625 Protein ID WP_013009346.1
Coordinates 28161..28439 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag N5O74_RS26620 Protein ID WP_000079928.1
Coordinates 27892..28161 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O74_RS26590 (23141) 23141..24369 + 1229 WP_102384962.1 IS3 family transposase -
N5O74_RS26595 (24422) 24422..24565 + 144 Protein_16 transposase -
N5O74_RS26600 (24705) 24705..24824 - 120 Protein_17 IS256 family transposase -
N5O74_RS26605 (25013) 25013..26626 + 1614 WP_058100863.1 IS66-like element ISEc23 family transposase -
N5O74_RS26610 (26776) 26776..27297 + 522 Protein_19 site-specific integrase -
N5O74_RS26615 (27417) 27417..27905 + 489 WP_226474140.1 transposase -
N5O74_RS26620 (27892) 27892..28161 + 270 WP_000079928.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
N5O74_RS26625 (28161) 28161..28439 + 279 WP_013009346.1 type II toxin-antitoxin system toxin YacB Toxin
N5O74_RS26630 (28635) 28635..28931 - 297 WP_001419651.1 hypothetical protein -
N5O74_RS26635 (29276) 29276..29863 + 588 WP_001418189.1 serine acetyltransferase -
N5O74_RS26640 (30145) 30145..30738 - 594 WP_000517696.1 ProQ/FINO family protein -
N5O74_RS26645 (31092) 31092..32438 + 1347 WP_054413039.1 protein YagA -
N5O74_RS26650 (32717) 32717..33076 + 360 WP_166738711.1 colicin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..103229 103229


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10748.35 Da        Isoelectric Point: 8.4615

>T258207 WP_013009346.1 NZ_CP104511:28161-28439 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
VLRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.50 Da        Isoelectric Point: 7.3210

>AT258207 WP_000079928.1 NZ_CP104511:27892-28161 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References