Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1812..2347 Replicon plasmid p2
Accession NZ_CP104511
Organism Escherichia coli strain E2

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag N5O74_RS26525 Protein ID WP_000222771.1
Coordinates 2060..2347 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag N5O74_RS26520 Protein ID WP_001139206.1
Coordinates 1812..2063 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O74_RS26515 (1) 1..858 + 858 WP_024233440.1 incFII family plasmid replication initiator RepA -
N5O74_RS26520 (1812) 1812..2063 + 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N5O74_RS26525 (2060) 2060..2347 + 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5O74_RS26530 (2715) 2715..2828 - 114 Protein_3 alkaline phosphatase -
N5O74_RS26535 (2827) 2827..3032 + 206 Protein_4 hypothetical protein -
N5O74_RS26540 (3205) 3205..6702 - 3498 WP_134235364.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..103229 103229


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T258206 WP_000222771.1 NZ_CP104511:2060-2347 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT258206 WP_001139206.1 NZ_CP104511:1812-2063 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References