Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2321973..2322611 Replicon chromosome
Accession NZ_CP104509
Organism Escherichia coli strain E2

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N5O74_RS11850 Protein ID WP_000813794.1
Coordinates 2321973..2322149 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N5O74_RS11855 Protein ID WP_001270286.1
Coordinates 2322195..2322611 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O74_RS11830 (2317592) 2317592..2318767 - 1176 WP_001236265.1 BenE family transporter YdcO -
N5O74_RS11835 (2318859) 2318859..2319395 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
N5O74_RS11840 (2319468) 2319468..2321429 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N5O74_RS11845 (2321521) 2321521..2321751 - 231 WP_000494244.1 YncJ family protein -
N5O74_RS11850 (2321973) 2321973..2322149 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N5O74_RS11855 (2322195) 2322195..2322611 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N5O74_RS11860 (2322690) 2322690..2324096 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
N5O74_RS11865 (2324341) 2324341..2325486 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
N5O74_RS11870 (2325504) 2325504..2326517 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
N5O74_RS11875 (2326518) 2326518..2327459 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T258191 WP_000813794.1 NZ_CP104509:2321973-2322149 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT258191 WP_001270286.1 NZ_CP104509:2322195-2322611 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References