Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1150956..1151574 Replicon chromosome
Accession NZ_CP104509
Organism Escherichia coli strain E2

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N5O74_RS05785 Protein ID WP_001291435.1
Coordinates 1150956..1151174 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N5O74_RS05790 Protein ID WP_000344800.1
Coordinates 1151200..1151574 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O74_RS05750 (1146245) 1146245..1146817 + 573 WP_000779831.1 YbaY family lipoprotein -
N5O74_RS05755 (1146848) 1146848..1147159 - 312 WP_000409911.1 MGMT family protein -
N5O74_RS05765 (1147538) 1147538..1147891 + 354 WP_000878140.1 DUF1428 domain-containing protein -
N5O74_RS05770 (1147933) 1147933..1149483 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N5O74_RS05775 (1149647) 1149647..1150117 - 471 WP_000136192.1 YlaC family protein -
N5O74_RS05780 (1150233) 1150233..1150784 - 552 WP_000102564.1 maltose O-acetyltransferase -
N5O74_RS05785 (1150956) 1150956..1151174 - 219 WP_001291435.1 HHA domain-containing protein Toxin
N5O74_RS05790 (1151200) 1151200..1151574 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N5O74_RS05795 (1152120) 1152120..1155269 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N5O74_RS05800 (1155292) 1155292..1156485 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258189 WP_001291435.1 NZ_CP104509:c1151174-1150956 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT258189 WP_000344800.1 NZ_CP104509:c1151574-1151200 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References