Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 183603..184528 | Replicon | chromosome |
| Accession | NZ_CP104509 | ||
| Organism | Escherichia coli strain E2 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | N5O74_RS00870 | Protein ID | WP_014640052.1 |
| Coordinates | 184142..184528 (+) | Length | 129 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | - |
| Locus tag | N5O74_RS00865 | Protein ID | WP_001339382.1 |
| Coordinates | 183603..184112 (+) | Length | 170 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N5O74_RS00835 (178628) | 178628..179236 | + | 609 | WP_000646078.1 | transcriptional repressor LexA | - |
| N5O74_RS00840 (179309) | 179309..180634 | + | 1326 | WP_001326646.1 | MATE family efflux transporter DinF | - |
| N5O74_RS00845 (180750) | 180750..180959 | + | 210 | WP_001030593.1 | CsbD family protein | - |
| N5O74_RS00850 (181001) | 181001..181516 | - | 516 | WP_001295691.1 | zinc uptake transcriptional repressor Zur | - |
| N5O74_RS00855 (181834) | 181834..182819 | + | 986 | Protein_158 | DUF2713 domain-containing protein | - |
| N5O74_RS00860 (183182) | 183182..183286 | + | 105 | Protein_159 | tRNA-dihydrouridine synthase | - |
| N5O74_RS00865 (183603) | 183603..184112 | + | 510 | WP_001339382.1 | Panacea domain-containing protein | Antitoxin |
| N5O74_RS00870 (184142) | 184142..184528 | + | 387 | WP_014640052.1 | hypothetical protein | Toxin |
| N5O74_RS00875 (184568) | 184568..184741 | + | 174 | WP_000390069.1 | hypothetical protein | - |
| N5O74_RS00880 (184789) | 184789..185070 | - | 282 | WP_001093921.1 | pyocin activator PrtN family protein | - |
| N5O74_RS00885 (185111) | 185111..185977 | - | 867 | WP_001075213.1 | hypothetical protein | - |
| N5O74_RS00890 (186086) | 186086..186610 | - | 525 | WP_000008239.1 | 5'-deoxynucleotidase | - |
| N5O74_RS00895 (186738) | 186738..187562 | - | 825 | WP_000081270.1 | DUF2303 family protein | - |
| N5O74_RS00900 (187628) | 187628..187990 | - | 363 | WP_000135680.1 | protein YfdP | - |
| N5O74_RS00905 (188713) | 188713..189405 | - | 693 | WP_001020632.1 | XRE family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleG7' | 178628..235736 | 57108 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 129 a.a. Molecular weight: 14465.40 Da Isoelectric Point: 5.4833
>T258183 WP_014640052.1 NZ_CP104509:184142-184528 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
Download Length: 387 bp
Antitoxin
Download Length: 170 a.a. Molecular weight: 19576.29 Da Isoelectric Point: 5.3338
>AT258183 WP_001339382.1 NZ_CP104509:183603-184112 [Escherichia coli]
MAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHNVSLRSDPREMDAD
EVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS
MAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHNVSLRSDPREMDAD
EVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS
Download Length: 510 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|