Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4479068..4479686 Replicon chromosome
Accession NZ_CP104503
Organism Escherichia coli strain E1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N5O81_RS21770 Protein ID WP_001291435.1
Coordinates 4479068..4479286 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N5O81_RS21775 Protein ID WP_000344800.1
Coordinates 4479312..4479686 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O81_RS21735 (4474355) 4474355..4474927 + 573 WP_000779831.1 YbaY family lipoprotein -
N5O81_RS21740 (4474958) 4474958..4475269 - 312 WP_000409908.1 MGMT family protein -
N5O81_RS21750 (4475648) 4475648..4476001 + 354 WP_000878140.1 DUF1428 domain-containing protein -
N5O81_RS21755 (4476043) 4476043..4477593 - 1551 WP_001298569.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N5O81_RS21760 (4477757) 4477757..4478227 - 471 WP_000136192.1 YlaC family protein -
N5O81_RS21765 (4478343) 4478343..4478894 - 552 WP_000102539.1 maltose O-acetyltransferase -
N5O81_RS21770 (4479068) 4479068..4479286 - 219 WP_001291435.1 HHA domain-containing protein Toxin
N5O81_RS21775 (4479312) 4479312..4479686 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N5O81_RS21780 (4480231) 4480231..4483380 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
N5O81_RS21785 (4483403) 4483403..4484596 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258176 WP_001291435.1 NZ_CP104503:c4479286-4479068 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT258176 WP_000344800.1 NZ_CP104503:c4479686-4479312 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References