Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2086108..2086762 Replicon chromosome
Accession NZ_CP104503
Organism Escherichia coli strain E1

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag N5O81_RS10100 Protein ID WP_000244781.1
Coordinates 2086108..2086515 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N5O81_RS10105 Protein ID WP_000354046.1
Coordinates 2086496..2086762 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O81_RS10080 (2082065) 2082065..2083798 - 1734 WP_000813193.1 single-stranded-DNA-specific exonuclease RecJ -
N5O81_RS10085 (2083804) 2083804..2084514 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5O81_RS10090 (2084539) 2084539..2085435 - 897 WP_000806633.1 site-specific tyrosine recombinase XerD -
N5O81_RS10095 (2085547) 2085547..2086068 + 522 WP_001055874.1 flavodoxin FldB -
N5O81_RS10100 (2086108) 2086108..2086515 - 408 WP_000244781.1 protein YgfX Toxin
N5O81_RS10105 (2086496) 2086496..2086762 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N5O81_RS10110 (2087005) 2087005..2087985 + 981 WP_000886078.1 tRNA-modifying protein YgfZ -
N5O81_RS10115 (2088062) 2088062..2088721 - 660 WP_000250274.1 hemolysin III family protein -
N5O81_RS10120 (2088885) 2088885..2089196 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
N5O81_RS10125 (2089241) 2089241..2090674 + 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T258167 WP_000244781.1 NZ_CP104503:c2086515-2086108 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT258167 WP_000354046.1 NZ_CP104503:c2086762-2086496 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References