Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 132831..133366 Replicon plasmid p1
Accession NZ_CP104501
Organism Escherichia coli strain E9

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag N5O75_RS25865 Protein ID WP_086589906.1
Coordinates 132831..133118 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N5O75_RS25870 Protein ID WP_086589907.1
Coordinates 133115..133366 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O75_RS25835 (N5O75_25840) 128048..129435 - 1388 Protein_124 phosphoethanolamine transferase CptA -
N5O75_RS25845 (N5O75_25850) 130775..131053 - 279 Protein_126 hypothetical protein -
N5O75_RS25850 (N5O75_25855) 131142..131624 - 483 Protein_127 glycosyltransferase -
N5O75_RS25855 (N5O75_25860) 131763..132044 - 282 WP_165467340.1 hypothetical protein -
N5O75_RS25860 (N5O75_25865) 132173..132602 - 430 Protein_129 transposase -
N5O75_RS25865 (N5O75_25870) 132831..133118 - 288 WP_086589906.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5O75_RS25870 (N5O75_25875) 133115..133366 - 252 WP_086589907.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N5O75_RS25880 (N5O75_25885) 134982..135203 + 222 WP_130549476.1 hypothetical protein -
N5O75_RS25885 (N5O75_25890) 136671..137474 + 804 WP_089540469.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(6)-Id / aph(3'')-Ib etpB 1..281548 281548
- inside IScluster/Tn - - 129449..138468 9019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11011.98 Da        Isoelectric Point: 10.3859

>T258156 WP_086589906.1 NZ_CP104501:c133118-132831 [Escherichia coli]
MTYAVKFRDDALKEWLKLDKSVQQQFAKKLKKCSENPHIPSARLHGLKDCYKIKLRASGFRLVYQVIDDMLIIAIVAVGK
RERNNVYNLASERMG

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9302.54 Da        Isoelectric Point: 4.0927

>AT258156 WP_086589907.1 NZ_CP104501:c133366-133115 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVNAGEGYPVAILNRNQPAFYCVPAELYERMFDALDDQELVKLVTERCNQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References