258155

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 124822..125357 Replicon plasmid p1
Accession NZ_CP104501
Organism Escherichia coli strain E9

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag N5O75_RS25815 Protein ID WP_086589903.1
Coordinates 125070..125357 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID L4J0V6
Locus tag N5O75_RS25810 Protein ID WP_001132895.1
Coordinates 124822..125073 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O75_RS25780 (N5O75_25785) 119892..121048 + 1157 Protein_113 transposase -
N5O75_RS25785 (N5O75_25790) 121085..121510 - 426 WP_086589901.1 antirestriction protein -
N5O75_RS25790 (N5O75_25795) 121584..121757 + 174 Protein_115 DUF4113 domain-containing protein -
N5O75_RS25795 (N5O75_25800) 121898..122860 - 963 WP_000756325.1 ParB family protein -
N5O75_RS25800 (N5O75_25805) 122857..124062 - 1206 WP_000817642.1 AAA family ATPase -
N5O75_RS25805 (N5O75_25810) 124436..124648 + 213 WP_000402944.1 hypothetical protein -
N5O75_RS25810 (N5O75_25815) 124822..125073 + 252 WP_001132895.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N5O75_RS25815 (N5O75_25820) 125070..125357 + 288 WP_086589903.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5O75_RS25820 (N5O75_25825) 125359..125770 + 412 Protein_121 DDE-type integrase/transposase/recombinase -
N5O75_RS25825 (N5O75_25830) 126413..127390 + 978 WP_086589904.1 RepB family plasmid replication initiator protein -
N5O75_RS25830 (N5O75_25835) 127669..128102 - 434 Protein_123 site-specific integrase -
N5O75_RS25835 (N5O75_25840) 128048..129435 - 1388 Protein_124 phosphoethanolamine transferase CptA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(6)-Id / aph(3'')-Ib etpB 1..281548 281548
- inside IScluster/Tn - - 129449..138468 9019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11210.25 Da        Isoelectric Point: 10.4703

>T258155 WP_086589903.1 NZ_CP104501:125070-125357 [Escherichia coli]
MRYQVKFREDALKEWQKLDKTIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGLRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9178.47 Da        Isoelectric Point: 4.2108

>AT258155 WP_001132895.1 NZ_CP104501:124822-125073 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQPLHDVDLD
KYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB L4J0V6

References